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The Trouble With Placebos

The latest NEJM fea­tures a big story about a small trial, with only 39 patients in the end, on the potential for placebos to relieve patients’ expe­rience of symptoms. This follows other recent reports on the sub­jective effec­tiveness of pseudo-​​pharmacology.

My point for today is that placebos are prob­lematic in health care with few excep­tions. First, in clinical trials, patients some­times agree to take what might be a placebo so that researchers can measure effects of a drug, by com­parison. A second instance is, pos­sibly, when doctors treat children. Even then, I’m not sure it’s wise to “train” kids to take a pill and expect to feel better.

The rela­tionship of an adult patient with a physician involves, or should involve, trust and mutual respect. A person cannot pos­sibly give informed consent for a treatment he or she doesn’t know about. So if the doctor’s giving a placebo to the patient, and making the decision for the patient because it might help, that dimin­ishes the patient’s autonomy, or self-​​determination. In simpler terms, it’s condescending.

You might con­sider the hypothesis that there’s nothing wrong with some­thing if it makes you, or someone else, feel better. But that’s kind of like saying the ends justify the means.

A placebo is, by def­i­n­ition, manip­u­lative. I wouldn’t want any doctor to treat me that way.

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