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Limiting Chemotherapy in Patients Who Aren’t Responding

This is the sixth post on Bending the Cost Curve in Cancer Care, based on the 10 sug­ges­tions put forth by Drs. Smith and Hillner in the May 26 NEJM.  We’re up to number 5 on the list for changing oncol­o­gists’ behavior: by lim­iting further chemotherapy to clinical trial drugs in patients who are not responding to three con­sec­utive reg­imens.

They’re right.

Giving one drug or com­bi­nation regimen, and then another, and another, and another, to cancer patients whose tumors resist mul­tiple reg­imens is more likely to cause harm than good. Oncologists need be real­istic with them­selves and with their patients, in a kindly way, when treat­ments fail.

Options to con­sider, besides chemo, include pal­li­ation (which can be started at any time, including before and during chemotherapy), alter­native approaches (such as hor­monal or immune-​​based therapy, for some tumors), hospice care and par­tic­i­pation in a clinical trial, as the authors suggest, based on the patient’s con­dition and preferences.

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