Some Articles I Authored A While Ago
This post, on my research in cancer immunology, is strangely personal.
At one level, what follows is nothing more than a list, a narrative if you will, a sketch of a formative chunk of my career and personal history. I’ve wanted to put this out there (here) for quite a while, but couldn’t: It’s been hard for me, harder in some ways than was the breast cancer and spine surgery and all the other unpleasant illnesses I haven’t mentioned yet, to come to grips with my near-hit academic medial research career that stopped, which until today has been for the most part disconnected from this blog and my new on-line life.
So here goes, a partial list of my publications, selected from ~30:
On a novel mechanism for B-cell death, my first first-author article based on my research in lymphoma immunology, in The Journal of Experimental Medicine, 1995:
CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway
On how “helper” T cells can kill some forms of malignant B cells, in Blood, 1996:
CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt’s lymphoma B cells
A solicited review of my early labwork, completed with my research mentor, in Immunologic Research, 1996:
Fas expression and apoptosis in human B cells
My first paper on CD40L and autoimmunity, in CLL, in Blood, 1998:
Chronic Lymphocytic Leukemia B Cells Can Express CD40 Ligand and Demonstrate T-Cell Type Costimulatory Capacity
A case report (as my lab and non-physical stature grew I became senior author), in the British Journal of Haemotology, 1998:
Novel association of haemophagocytic syndrome with Kaposi’s sarcoma-associated herpesvirus-related primary effusion lymphoma
On some experiments with mantle cell lymphoma cells, in Leukemia, 2000:
Proliferative response of mantle cell lymphoma cells stimulated by CD40 ligation and IL-4
The first major paper from my NIH-funded lab, in The Journal of Immunology, 2000:
Modulation of NF-kB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells
We sent this one to Science. They declined. So did a bunch of other journals. Eventually it came out in Blood, 2001:
Survival of leukemic B cells promoted by engagement of the antigen receptor
A nearly life-eating chapter that took up way too much of my time but was probably worthwhile nonetheless, on immunology, for a Neoplastic Hematopathology textbook, in 2001:
Immune System: Structure and Function
An interesting story, we thought, in Autoimmunity, 2002:
Inhibition of Fas-mediated apoptosis by antigen: implications for lymphomagenesis
A monograph I wrote around the time I got sick, on how malignant lymphocytes die, somewhat theoretical, in Cancer Investigation, 2002:
Apoptosis in Lymphocytic Leukemias and Lymphomas
For there record, there’s earlier and later stuff too, by me alone and with others, and (sadly) reams of unpublished data, mainly from 1997 – 2002. These are the published papers I consider most my own.
Looking back, I’m pretty sure we were right, at least on most of these findings.
(Is there an opposite-of-decline effect?)
I’ve often wondered how differently things might have turned out if there’d been blogs and open-access journals with real-time comments when we in my lab were trying to get our work published in top, grant-renewing, tenure-securing journals.
Well, now that this is done, I can keep moving forward!
With gratitude to my colleagues who collaborated, and especially to those who worked with me in the lab,
The most important thing is that it’s work you can be proud of. Thanks for sharing it!
Thanks Peggy, It’s true, I am proud of all that.