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The Music of HIV

Yes­terday I came upon some­thing I’d never heard before: Alexandra Pajak, a graduate student at the Uni­versity of Georgia, merges art and science in a novel way. She com­posed a new work, the Sounds of HIV, based on the virus’s genetic sequence.

A CD, pro­duced by Azica records, will be available later this month. A Sci­enceRoll post, by Bertalan Meskó, clued me into this fas­ci­nating project. He shared the artist’s expla­nation of her work:

Sounds of HIV is a musical trans­lation of the genetic code of HIV, the Human Immun­od­e­fi­ciency Virus.  Every segment of the virus is assigned music pitches that cor­re­spond to the segment’s sci­en­tific prop­erties.  In this way, the sounds reflect the true nature of the virus.  When lis­tening from beginning to end, the lis­tener hears the entire genome of HIV.

In English, the nucleotides Adenine, Cytosine, Uracil/​Thymine, and Guanine are abbre­viated with the letters A, C, T, and G.  Since A, C, and G are also musical pitches in the Western melodic scale, these pitches were assigned to the matching nucleotides.  To form two perfect fifths (C-​​G and D-​​A), “D” was arbi­trarily assigned to musi­cally rep­resent Uracil.  I assigned the pitches of the A minor scale to the amino acids based on their level of attraction to water…

According to a May, 2010 post in the Daily Scan, the artist has assigned pitches to each viral segment’s properties:

…The composition’s Prelude and Postlude cor­re­spond to the first and last 100 nucleotides, and the sec­tions named after the pro­teins (Pro­teins 1–9) rep­resent trans­la­tions of the amino acid sequences…

Upon searching further, I tracked down some partial HIV music clips, available now, at Clas­sic­sOnline. The start of the prelude sounds calm and lovely to my rock-​​trained ears; other por­tions are dis­tinct and lively.

I look forward to more listening!

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