The Feb 1 issue of JAMA includes a major report on the practice of lumpectomy in the U.S. The study examined what happened to 2,206 women at four medical centers who opted for breast-conserving surgery at the time of breast cancer diagnosis. The main finding was that after lumpectomy, nearly one in four women had another operation to remove cancerous cells in the breast. Among all the breast cancer patients who began with a lumpectomy, 8.5% wound up with a mastectomy.
These are staggeringly high rates of re-operation in women who opted for small procedures to begin with. Many of the women who had additional procedures did so for concern over having “clean margins” – that upon removal of a tumor, the edges of the specimen don’t reveal malignant cells. Re-excision for patients with negative margins varied by hospital; at one medical center the re-excision rate was 1.7%, at another it was 20.9%. Analysis by surgeon revealed huge variation, with re-excision rates ranging between 0 and 70%. The incidence of positive margins was 14%.
What further clouds the story is that among women who did have positive margins, meaning that cancerous cells were evident along the edge of the lump removed, nearly 15% didn’t have a second procedure. The big picture is that there was little pattern – or reason evident, at least at the collective level – for the surgeries and decisions to re-operate after lumpectomy for breast cancer.
The study, funded by the NIH, was sufficiently large to merit concern. It involved careful chart and pathology review of the specimens through a consortium of four medical centers around the country: the University of Vermont, Kaiser Permanente Colorado, Group Health in Washington State and the Marshfield Clinic in Wisconsin. And it reflects current practice; the surgeries took place between 2003 and 2008.
Lumpectomy is a very common procedure - and a significant issue, in terms of costs, and risks, and decisions women make every day upon receiving a new BC diagnosis. An estimated 60–70% of newly-diagnosed breast cancer patients choose breast-conserving surgery. So we’re talking about 160,000 or so lumpectomies per year in the U.S. (very approximate, ES: 2⁄3 of 240,000 new BC cases). The variable results affect cosmetic outcome – the very reason many women choose lumpectomy to begin with and, potentially, the rate of BC recurrence.
The authors discuss: “Our finding…suggests that patients under similar clinical conditions are likely to undergo reexcision based on the treating surgeon and not just the clinical characteristics.” They offer possible explanations, including differences in surgical training, surgeons’ confidence in their operative techniques, how tumors are assessed in the operating room, and variation in how pathologists review specimens and “call” the margins positive or negative.
All of this meshes with my experience – knowing women who’ve had breast-conserving surgery and then got mixed information about the results and what to do next. You’d think lumpectomy would be a standard procedure by now, and that decisions about what to do after the procedure, surgically speaking (let alone decisions about chemo, hormonal treatments and radiation) would be straightforward in most cases.
—
This is a very real issue.
My mother had 2 lumpectomy/reexcision surgeries for her BC and her margins remained positive and so rather than trying another breast conserving surgery, she opted that her third surgery was a mastectomy.
Having not the greatest health insurance, she had to bear a 20% co-insurance burden for these 3 procedures which added to the depression she already had over “her body turning on her.”
I’m curious as to the difference between her experience at a regional hospital versus what might be the outcomes of having a better pathology / surgical staff environment at a more metropolitan hospital?
You raise an interesting point, Ed. The study examined lumpectomies at just four centers.
Either scenario seems plausible. Doctors at a small medical center might be less confident and do more re-excisions. On the other hand, it’s easy to envision a woman going to a cancer center for a second opinion where the doctors might say or suggest the first procedure was inadequate. But I’m not aware of real data on this.
[…] getting care that is not equal. - Study Finds Wide Variation in Reoperation Rates after Lumpectomy – Medical […]
[…] Study Finds Wide Variation in Reoperation Rates after Lumpectomy - Medical […]